【关键词】 骨细胞 Effect of substance P on proliferation and activity of osteoblasts in vitro 【Abstract】 AIM: To observe the effect of substance P (SP) on the proliferation and activity of osteoblasts cultured in vitro. METHODS: The calvarium bone of newborn rats was digested with bacterial collagenase and cultured to obtain osteoblasts and SP with different concentrations was ..